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Amyloid Toxicity Inhibitor Peptide 110
| Overview | |
|---|---|
| Description | This peptide is a modification of the amyloid toxicity inhibitor peptide 11 with Trp4 and Trp8 replacing Gly4 and Gly8 of the original peptide. This peptide is highly effective in blocking beta-amyloid 1 to 40 fibrillization. It is the most effective inhibitor among the amyloid toxicity inhibitor peptides group. The observation that the peptide 110 is able to depolymerize mature b-amyloid 1 to 40 supports the view that these are dynamic structures and suggests that targeting beta-sheet packing may be an effective strategy for depolymerizing amyloid plagues. |
| Sequence | RGTWEGKW-NH2 |
| Sequence (3 Letter) | H-Arg-Gly-Thr-Trp-Glu-Gly-Lys-Trp-NH2 |
| Molecular Weight | 1018.2 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Sato, T. et al. Biochem. 45, 5509 (2006).
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InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.