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Pep - 1 - Cysteamine
Ac - KETWWETWWTEWSQPKKKRKV - cysteamine
| Overview | |
|---|---|
| Description | Pep-1 is one of the synthetic cell-penetrating peptides (CPPs), which has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive way. It is a CPP with primary amphipathicity (i.e amphipathicity resulting from the amino acid sequence itself, not from the folding structure) that comprises a tryptophan-rich so-called €˜hydrophobic €™ domain, a hydrophilic domain derived from an NLS (nuclear localization signal) of SV40 (simian virus 40) large T-antigen, and a spacer between them. A cysteamine group is present at the C-terminus. The presence of cysteamine group in C terminal seems to play a crucial role in the delivery efficiency of cargoes into cells. |
| Sequence | Ac-KETWWETWWTEWSQPKKKRKV-cysteamine |
| Sequence (3 Letter) | Ac - Lys - Glu - Thr - Trp - Trp - Glu - Thr - Trp - Trp - Thr - Glu - Trp - Ser - Gln - Pro - Lys - Lys - Lys - Arg - Lys - Val - cysteamine |
| Molecular Weight | 2949.5 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Henriques, S. et al. FEBS Letters Vol. 579, 4498 (2005).
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.