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Cys(Npys) - (Arg)9
C(Npys)RRRRRRRRR - NH2
| Overview | |
|---|---|
| Description | This is a peptide comprising of 9 Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Coupling of sulfhydrils has been studied as an effective means to deliver/release therapeutics such as siRNA in the reducing environment within the cell. For example, in a study leukemic-specific SiRNA was delivered by the formation of immunocomplexes that consisted of targeted antibody conjugated to oligo-9-Arg peptides. |
| Sequence | C(Npys)RRRRRRRRR-NH2 |
| Sequence (3 Letter) | H - Cys(Nyps) - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - NH2 |
| Molecular Weight | 1680.1 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Lee KY. et al. Mol & Cells. 29(5):457-462 (2010).
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.