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Bid BH3 - R8
| Overview | |
|---|---|
| Description | Bid BH3 is a pro-apoptotic member of the "BH3-only" subset of BCL-2 family proteins that constitute a critical control point in apoptosis. BID BH3 interacts with Bax to induce mitochondrial outer membrane permeabilization in the apoptotic process. This peptide contains 8 Arg residues in the L-isomeric form on the N-terminus. BID Tagging with poly-arginine facilitates cell internalization. R8BIDH3 has been shown to induce apoptosis of Jurkat leukemia cells in vitro. |
| Sequence | RRRRRRRRGEDIIRNIARHLAQVGDSMDR |
| Sequence (3 Letter) | H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg-OH |
| Molecular Weight | 3616.2 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Letai, A. J Clin Invest 115, 2648 (2005). Goldsmith, K. et al. Proc Amer Assoc Cancer Res 45,1829 (2004). Goldsmith, K. et al. Oncogene 25, 4525 (2006).
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.