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SHU 9119
| Overview | |
|---|---|
| Description | The efficacy and specificity of SHU-9119 as an MC3/MC4 receptor antagonist in the rat was first validated in vitro and in vivo. In vitro, in heterologous cells expressing either rat MC3-R or MC4-R, the major MCR subtypes expressed in brain, SHU-9119 showed no intrinsic agonism. |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Nal(2')-Arg-Trp-Lys]-NH2 |
| Molecular Formula | C54H71N15O9 |
| C Terminal | Amidation |
| N Terminal | Acetylation |
| Disulfide Bridge | Asp2-Lys7 |
| Molecular Weight | 1074.23 |
| Properties | |
| Purity | > 95% |
| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
| Storage | Storage at -20°C. Keep tightly closed. |
| Note | Antagonist of rat MC3 and mouse MC4 receptors. |
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