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Conantokin G
GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN - NH2
| Overview | |
|---|---|
| Description | Conantokin G (Con G) toxin is a 17-amino-acid competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. It was isolated from the venom of Conus geographus and it belongs to a unique family of γ-carboxyglutamic acid-containing Conus peptides. |
| Sequence | GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH2 |
| Sequence (3 Letter) | H - Gly - Glu - Gla - Gla - Leu - Gln - Gla - Asn - Gln - Gla - Leu - Ile - Arg - Gla - Lys - Ser - Asn - NH2 |
| Molecular Weight | 2264.2 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Ref: Skjærbæk, N. et al. J. Biol. Chem. 272, 2291 (1997). Donevan, S. and R. McCabe, R. Mol. Pharmacol. 58, 614 (2000). Hammerland, L. et al. Euro. J. Pharmacol. 226, 239 (1992); Blandl, T. et al. FEBS Lett. 435, 257 (1998); Lin, C. et al. Protein Engineering 12, 589 (1999).
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