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Overview | |
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Description | This is amino acids 676 to 700 fragment of steroid receptor co-activator (SRC1). This N-terminnaly biotinylated peptide is derived from the second LXXLL motif of SRC1. Co-activator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription. A short amphipathic beta-helical domain that includes this LXXLL motif serves as the interaction interface between the co-activator molecules and the ligand-dependent activation function (AF-2) located in the COOH-terminus of the nuclear receptor ligand-binding domain (LBD). Receptor binding domain of the co-activator SRC-1 is specifically recruited to the farnesoid X receptor (FXR) ligand-binding domain. |
Sequence | Biotin-CPSSHSSLTERHKILHRLLQEGSPS |
Sequence (3 Letter) | Biotin - Cys - Pro - Ser - Ser - His - Ser - Ser - Leu - Thr - Glu - Arg - His - Lys - Ile - Leu - His - Arg - Leu - Leu - Gln - Glu - Gly - Ser - Pro - Ser - OH |
Molecular Weight | 3026.5 |
Properties | |
Purity | % Peak Area By HPLC ≥ 95% |
Storage | -20 °C |
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