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Angiotensin II Substrate
DRV - pY - IHPF
| Overview | |
|---|---|
| Description | This is a tyrosine phosphorylated angiotensin II peptide with a substrate sequence specificity for chymase to act. This is an octapeptide hormone that is formed as a result of the action of human heart chymase, a chymotrypsin-like serine protease on the Phe-His bond of Angiotensin I. The ideal susbtrate for human heart chymase should contain this peptide sequence, and has been demonstrated that the Pro-Phe sequence in P2-P1 positions of peptide substrates is highly favored by leukocyte chymotrypsin-like proteinases such as chymases and cathepsin G. |
| Sequence | DRV-pY-IHPF |
| Sequence (3 Letter) | H - Asp - Arg - Val - pTyr - Ile - His - Pro - Phe - OH |
| Molecular Weight | 1126.2 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
1, Kinoshita A, et al. J Biol Chem 266(29): 19192-19197 (1991).
2, Ruzzene, M. et al. Eur. J. Biochem. 211, 289 (1993).
2, Ruzzene, M. et al. Eur. J. Biochem. 211, 289 (1993).
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