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Orexin B, mouse
| Overview | |
|---|---|
| Description | Orexins are synthesized by posterolateral neurons in hypothalamus. They bind to orexin-1 (OxR1) and orexin 2 (OxR2) receptors. Orexin A can bind to both OxR1 and OxR2 while Orexin B can associate with OxR2 only. Both Orexins are involved in the regulation of arousal and sleep states, energy homeostasis, and autonomic central control. |
| Sequence | RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2 |
| Sequence (3 Letter) | Arg - Pro - Gly - Pro - Pro - Gly - Leu - Gln - Gly - Arg - Leu - Gln - Arg - Leu - Leu - Gln - Ala - Asn - Gly - Asn - His - Ala - Ala - Gly - Ile - Leu - Thr - Met - NH2 |
| Molecular Weight | 2937.4 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | €“20 °C |
1. Martynska L., et.al., Neuroendocr Lett 4(26), 289-292 (2005).
2. Ebrahim I.O., et.al., J of Royl Soc of Med95, 227-230 (2002).
3. Chiou L-C., et.al., Cur Pharm Des16(28), 3089-3100 (2010).
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