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[Lys(Me3)27 - Histone H3 (23 - 34) - GGK(Biotin)
| Overview | |
|---|---|
| Description | This is histone H3 (23-34) trimethylated at Lys27 and biotinylated on the C-terminus through a GGK linker. Trimethylation of Lys27 promotes Polycomb protein (Pc)-chromatin association. This modification has also been shown to be associated with methylated CpG island genes in cancer cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form. |
| Sequence | KAAR-K(Me3)-SAPATGGGG-K(Biotin) |
| Sequence (3 Letter) | H-Lys-Ala-Ala-Arg-Lys(Me3)-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Gly-Gly-Lys(Biotin)-OH |
| Molecular Weight | 1624.9 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Schlesinger, Y. et al. Nat Genet 39, 232 (2007); Zhang, X. et al. Nat Struct Mol Biol 14, 869 (2007); Min, J. et al. Genes Dev 17, 1823 (2003).
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