![[Lys(Me2)79] - Histone H3 (58 - 89) - GGK(Biotin)](/media/com_eshop/products/resized/prod_150x150-500x500.png "[Lys(Me2)79] - Histone H3 (58 - 89) - GGK(Biotin)")
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[Lys(Me2)79] - Histone H3 (58 - 89) - GGK(Biotin)
| Overview | |
|---|---|
| Description | This peptide is histone H3 58-89 with dimethylation at Lys79 and biotin-labeled through a C-terminal GGK linker. Lys79 methylation is mediated by DOT1 protein. It has been shown that dimethylation at Lys79 is important for transcriptional activation via mixed lineage leukemia gene (MLL)-ENL-ER and MLL-AF9. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form. |
| Sequence | TELLIRKLPFQRLVREIAQDF-K(Me2)-TDLRFQSAAIGG-K(Biotin) |
| Sequence (3 Letter) | H-Thr-Glu-Leu-Leu-Ile-Arg-Lys-Leu-Pro-Phe-Gln-Arg-Leu-Val-Arg-Glu-Ile-Ala-Gln-Asp-Phe-Lys(Me2)-Thr-Asp-Leu-Arg-Phe-Gln-Ser-Ala-Ala-Ile-Gly-Gly-Lys(Biotin)-OH |
| Molecular Weight | 4314.1 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Milne, T. et al. Cancer Res 65, 11367 (2005); Schubeler, D. et al. Gene Dev 18, 1263 (2004); Feng, Q. et al. Curr Biol 12, 1052 (2002).
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