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Product Code: 1816-003

Price: $61.00

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Overview
Description This peptide is histone H3 (44-63) with acetylation at Lys56. Lys56 acetylation occurs during premeiotic and mitotic S phases and persists through DNA damage repair and is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex. A deficiency of acetylated Lys56 in histone H3 is implicated in spontaneous chromosome breaks during mitosis, suggesting that this modification is important for replisome integrity and DNA replication.
Sequence GTVALREIRRYQ-K(Ac)-STELLIR
Sequence (3 Letter) H-Gly-Thr-Val-Ala-Leu-Arg-Glu-Ile-Arg-Arg-Tyr-Gln-Lys(Ac)-Ser-Thr-Glu-Leu-Leu-Ile-Arg-OH
Molecular Weight 2444.9
Properties
Purity > 95% By HPLC
Storage Store at -20 °C, cap vial tightly at all times.
Han, J. et al. J Biol Chem 282, 28587 (2007); Schneider, J. et al. J Biol Chem 281, 37270 (2006).

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