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Amyloid Precursor Protein, (APP) (667 - 676), FRET peptide
| Overview | |
|---|---|
| Description | This amino acids 667 to 676 fragment of the amyloid precursor protein (APP) is a beta secretase substrate containing an Mca/ Dap(Dnp) FRET pair. Beside being cleaved by beta-site APP cleavage enzyme (BACE) between the Met and Asp residues, it can also be cleaved by the enzyme thimet oligopeptidase (TOP), Ex/Em=330 nm/390 nm. |
| Sequence | Mca-SEVKMDAEFR-Dap(Dnp)-NH2 |
| Sequence (3 Letter) | Mca-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-DAP(DNP)-NH2 |
| Molecular Weight | 1678.8 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Koike, H. et al. J. Biochem. 126, 235 (1999), Grüninger-Leitch, F. et al. J. Biol. Chem. 277, 4687 (2002), Verheijen, J. et al. Clin. Chem. 52, 1168 (2006).
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