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E1, (E257)
| Overview | |
|---|---|
| Description | This peptide is an antagonist variant of OVA (257-264). It induces positive selection on the beta 2M (-/-), and negative selection on beta 2M (+/-) background. This peptide was used to study the ability of the wild-type or mutant TCRs to transduce signals leading to positive or negative selection, and was utilized in several thymocyte development studies. E1 presentation leads to Egr-1 induction and ERK phosphorylation. |
| Sequence | EIINFEKL |
| Sequence (3 Letter) | H-Glu-Ile-Ile-Asn-Phe-Glu-Lys-Leu-OH |
| Molecular Weight | 1005.2 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Canté-Barrett, K. et al. J. Immunol. 176, 2299 (2006); Worlen, G. et al. Nature 406, 422 (2000); Starr, T. et al. J. Immunol. 171, 4512 (2003).
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