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Tat - C (48 - 57)
CGRKKRRQRRR
| Overview | |
|---|---|
| Description | This peptide is amino acids 48 to 57 fragment of TAT with an additional cysteine residue at the N-terminus. This peptide contains the protein transduction domain (PTD) of the HIV Tat protein that inhibits HSV-1 entry. The addition of a cysteine residue to the N-terminus of the Tat-PTD (Tat-C peptide) improves the antiviral activity against HSV-1 and HSV-2. Tat-C acts extracellularly, blocking entry of adsorbed virus immediately without eluting virions. |
| Sequence | CGRKKRRQRRR |
| Sequence (3 Letter) | H - Cys - Gly - Arg - Lys - Lys - Arg - Arg - Gln - Arg - Arg - Arg - OH |
| Molecular Weight | 1499.8 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Bultmann, H. et al. Antimicrob. Agents Chemother. 51, 1596 (2007).
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