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Protease - Activated Receptor - 3, PAR - 3 Agonist, amide
SFNGGP - NH2
| Overview | |
|---|---|
| Description | This peptide is one of the four PAR sub-types, and is acted upon by thrombin; not trypsin. It is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. PARs have been studied for their roles in itch and, their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR4. Co-expression of PAR3 and PAR4 enhances thrombin action suggesting that PAR3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR4. |
| Sequence | SFNGGP-NH2 |
| Sequence (3 Letter) | H - Ser - Phe - Asn - Gly - Gly - Pro - NH2 |
| Molecular Weight | 576.6 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
1, Tsujii, K. et al. J Pharmacol Sci. 108:385-388 (2008).
2, Leger, AJ. et al. Circ, 114:1070-1077 (2006).
2, Leger, AJ. et al. Circ, 114:1070-1077 (2006).
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InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.