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Human PD - L1 inhibitor III NEW
| Overview | |
|---|---|
| Description | Programed cell death protein 1 (PD-1) is a cell surface receptor. PD-1 and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immunosurveillance mechanism. Human PD-L1 inhibitor III is a peptide-based molecule. It binds to human PD-1 and inhibits PD-1/PD-L1 binding. This peptide, hPDL-1 inhibitor III has anchor residues (underlined), TEKDYRHGNIRMKLAYDL that influence binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway has become a popular approach toward cancer treatment.PD-L1 Related PeptidesHuman PD-L1 inhibitor I, Cat# AS-65581Human PD-L1 inhibitor II, Cat# AS-65582Human PD-L1 inhibitor IV, Cat# AS-65584Human PD-L1 inhibitor V, Cat# AS-65585 |
| Sequence | TEKDYRHGNIRMKLAYDL |
| Sequence (3 Letter) | H - Thr - Glu - Lys - Asp - Tyr - Arg - His - Gly - Asn - Ile - Arg - Met - Lys - Leu - Ala - Tyr - Asp - Leu - OH |
| Molecular Weight | 2223.7 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Bardhan K., et.al, Front Immunol 7(550), (2016); Li Q., et.al, Oncotarget 7(40), 64967-64976 (2016); D'Errico G., et.al, Clin Transl Med 6(1), 3-12 (2017)
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.