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CKS - 17 (dimer), MN10021
LQNRRGLDLLFLKEGGLC (dimer)
| Overview | |
|---|---|
| Description | A dimer of CKS-17 has a natural occurring cysteine at the carboxyl terminus (where it occurs in the retroviral peptides on which CKS-17 is based) and dimerization is accomplished by cysteine-disulfide linkage. CKS-17 is a synthetic retroviral envelope heptadecapeptide corresponding to a region highly conserved in retroviral transmembrane proteins such as pl5E. The CKS-17 peptide has been previously shown to inhibit monocyte superoxide production, natural killer cell activity, polyclonal B-cell activation, and monocyte-mediated killing by inactivation of interleukin-1. |
| Sequence | LQNRRGLDLLFLKEGGLC (dimer) |
| Sequence (3 Letter) | H - Leu - Gln - Asn - Arg - Arg - Gly - Leu - Asp - Leu - Leu - Phe - Leu - Lys - Glu - Gly - Gly - Leu - Cys - OH |
| Molecular Weight | 4088.8 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Nelson, M. et al. Cancer Immunol Immunother 30, 113 (1989).
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