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PUMA BH3
| Overview | |
|---|---|
| Description | This is a PUMA (p53 upregulated modulator of apoptosis) BH3 domain peptide. PUMA together with Bcl-xL, and cytoplasmic p53 coordinates p53 functions. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
| Sequence | EEQWAREIGAQLRRMADDLNAQYER |
| Sequence (3 Letter) | H-Glu-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Leu-Arg-Arg-Met-Ala-Asp-Asp-Leu-Asn-Ala-Gln-Tyr-Glu-Arg-OH |
| Molecular Weight | 3049.3 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Chipuk, J. et al. Science 309, 1732 (2005), Nakano, K. et al. Mol. Cell 7, 683 (2001), Yu, J. et al. Mol. Cell 7, 673 (2001), Han, J. et al. Proc. Natl. Acad. Sci. U S A. 98, 11318 (2001).
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.