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HIF - 1 {alpha} (556 - 574)
| Overview | |
|---|---|
| Description | This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in response to a lack of oxygen. This part of HIF-1 binds to the von Hippel-Lindau factor (VHL) an E3 ubiquitin ligase, and the proline 564 is absolutely critical to the binding process |
| Sequence | DLDLEMLAPYIPMDDDFQL |
| Sequence (3 Letter) | H-Asp-Leu-Asp-Leu-Glu-Met-Leu-Ala-Pro-Tyr-Ile-Pro-Met-Asp-Asp-Asp-Phe-Gln-Leu-OH |
| Molecular Weight | 2254.6 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Ref: Hirsilä, M. et al. J Biol. Chem 278, 30772 (2003); Robinson, B. Pediatric Research 50, 673 (2001).
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