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| Overview | |
|---|---|
| Synonyms | Endomorphin1; EM-1; EM1 |
| Description | Endomorphin-1 (EM-1) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. Endomorphin-1 activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2). However, endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor. |
| Cas No | 189388-22-5 |
| Sequence | {TYR}{PRO}{TRP}{PHE}-NH2 |
| Sequence Shortening | YPWF-NH2 |
| Molecular Formula | C34H38N6O5 |
| C Terminal | NH2 |
| Molecular Weight | 610.7 |
| Properties | |
| Purity | > 95% |
| Solubility | The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents. |
| Gmp Flag | 0 |
| Storage | Store the peptide at -20°C. Keep container tightly closed. |
| Note | Endomorphin-1 is a potent, selective endogenous μ opioid receptor agonist. |
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